Timosaponin AIII ( Timosaponin AIII )

产品货号. M18529 CAS No. 41059-79-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Timosaponin AIII
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Timosaponin AIII induces autophagy in HeLa cells followed by apoptotic cell death (IC50: 10 μM).
产品描述

Timosaponin AIII induces autophagy in HeLa cells followed by apoptotic cell death (IC50: 10 μM). The Timosaponin AIII cellular response is mediated via inhibition of mTORC1 and induction of ER stress (IC50: 2.5 μM, BT474 cells; 6 μM, MDAMB231). The Timosaponin AIII pro-apoptotic response is selective for tumor cells over normal cells but autophagy is induced in both.
同义词

Timosaponin AIII
通路

Others
靶点

Other Targets
受体

mTORC1
研究领域

Others-Field
适应症

——

CAS Number

41059-79-4
分子量

740.92
分子式

C39H64O13
纯度

98%
溶解度

——
SMILES

[C@]12([C@@H]3[C@H](C[C@H]1[C@H]1[C@H](CC2)[C@@]2([C@H](CC1)C[C@H](CC2)O[C@H]1[C@H](O[C@@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)O)O)CO)[C@H]([C@H]([C@H](O1)CO)O)O)C)O[C@@]1([C@H]3C)CC[C@H](CO1)C)C
化学全称

[(25S)-5-Spirostan-3-yl]2-O-(-D-glucopyranosyl)--D-galactopyranoside

1. Wu ZT, et al. Acta Pharmacol Sin. 2014 Sep;35(9):1188-98.

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